Mammalian cartilage synthesizes both proteoglycan and non-proteoglycan forms of type IX collagen

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Structural and functional comparison of type IX collagen-proteoglycan from chicken cartilage and vitreous humor.

Type IX collagen-proteoglycan is a major component of hyaline cartilages where it is located on the surface of the collagen fibrils so that a collagenous domain of the molecule (called COL3) and a non-collagenous domain (called NC4) project at periodic distances away from the surface of the fibril. Type IX collagen-proteoglycan is also present on the surface of the collagen fibrils of the adult...

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The future of biochemistry lies in understanding how single gene products associate and function together. Interactions in connective tissues, including those between the proteoglycans and collagens are especially piquant, evolutionarily conserved and physiologically significant. Connective tissues (e.g. skin, tendon, blood vessels, etc.) are systems of insoluble fibrils and soluble polymers wh...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1991

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj2780441